MUSCLE AND NERVE BIOPSIES
Wednesday 19 May 2021
Some of the pathologic changes in muscle can be seen on the H&E stain but histochemistry techniques are required to demonstrate disease states related to enzymes. Some of the pathologic changes in nerve biopsies can be seen with special stains and IHC stains but some changes can only be seen with an electron microscope.
1. Muscle Biopsy
2. Nerve Biopsy
1. Specimen Requisition
2. Specimen Bag with a biohazard label
3. Gauze or Telfa pad moistened with saline (not submerged).
• A 24-hour notice is requested. Biopsies cannot be accepted on Friday’s after 3 pm or prior to a public holiday.
• Submit a muscle biopsy specimen that is approximately 1.0 cm. in length and 0.5 cm. in width. The specimen should be gently laid on a gauze or Telfa pad moistened with saline (not submerged). Submitting the tissue on clamps is unnecessary.
• Nerve segments should be sent STAT to the laboratory. Call courier dispatch at 205-591-799 for a STAT pick-up. Biopsies should be delivered to the laboratory within one hour of collection.
• A copy of the patient’s clinical history must accompany the muscle or nerve biopsy.
• Muscle and nerve biopsies are sent to the University of Alabama in Birmingham for histochemistry and electron microscopy evaluation.